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KMID : 0828520110150020099
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Journal of the Korean Geriatrics Society
2011 Volume.15 No. 2 p.99 ~ p.106
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Relationship between Plasma Lipids and Osteoporosis in Korean Postmenopausal Women
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Lee Kyoung-Shik
Cho Jae-Hwan
Park Chang-Hae
Kim Bo-Seung
Cho Kyung-Hwan
Lee Seung-Hwan
Ko Byeong-Jun
Kim Do-Hoon
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Abstract
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Background :Osteoporotic fractures and cardiovascular diseases (CVD) are prevalent on elderly people. Recently, links between CVD and osteoporosis and between serum lipids and osteoporosis has been suggested. However, there are few studies about the relationship between bone mineral density (BMD) and serum lipids in Korea. The aim of this study was to evaluate the correlation of serum lipids levels with osteoporosis in Korean postmenopausal women.
Methods:This cross-sectional study consisted of 1,093 Korean postmenopausal women who visited a university hospital for medical checkup from March 2007 to March 2009. Anthropometric measurement and blood tests were performed for plasma lipids, fasting glucose, body mass index (BMI) and blood pressure. The BMD was measured by dual energy X-ray absorptiometry. After the subjects were classified into three groups by lumbar or femur BMD, the correlation between serum lipids and BMD was analyzed.
Results:Serum high density lipoprotein cholesterol (HDL-C) levels were significantly lower in osteoporosis group (52.74±13.94mg/dl) than other groups (osteopenia group: 56.22±13.40, normal group: 56.54±13.22mg/dl, P=0.007) when participants were grouped by lumbar BMD. In addition, serum triglyceride in osteoporosis group was higher than other groups. The results were statistically significant after adjustment for confounding factors such as age, BMI, blood pressure. But, there was no significant difference when grouped by femur BMD.
Conclusion:As lumbar BMD decreased, HDL-C also showed a tendency to decline, and triglyceride reversely to increase. Osteoporosis may play a role of the risk factor for CVD through the relation between the lumbar BMD and serum lipids.
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KEYWORD
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Osteoporosis, Postmenopausal women, Bone mineral density, High density lipoprotein cholesterol, Triglycerides
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